Article
A pilot experiment for the micronucleus test. The multi-sampling at multi-dose levels method.
Mutation research - 1 Jan 2000
Hayashi M, Sofuni T, Ishidate M
Abstract excerpt
A pilot experiment was undertaken to find the optimal dose range and sampling time in the micronucleus test; 2 animals per group were used. The chemical was injected at 4 different doses, and smear preparations were made from femoral marrow cells at 5 different sampling times for each dose group. The incidence of micronucleated polychromatic erythrocytes was scored on the preparations stained with acridine...
Topics
- Animals
- Cell Nucleus
- Erythrocytes
- Female
- Male
- Mice
- Mice, Inbred Strains
- Mutagenicity Tests
- Mutagens
- Mutation
- Sex Factors