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Article

Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A.

Biochemistry - 15 Mar 2011

Doucet Nicolas, Khirich Gennady, Kovrigin Evgenii L, Loria J Patrick

Abstract excerpt

The motion of amino acid residues on the millisecond (ms) time scale is involved in the tight regulation of catalytic function in numerous enzyme systems. Using a combination of mutational, enzymological, and relaxation-compensated (15)N Carr-Purcell-Meiboom-Gill (CPMG) methods, we have previously established the conformational significance of the distant His48 residue and the neighboring loop 1 in RNase A...

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PMID: 21250662
DOI: 10.1021/bi1018539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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