Article

Environmental Contributions to Proton Sharing in Protein Low-Barrier Hydrogen Bonds

2025-11-06

Abstract excerpt

Hydrogen bonds (H-bonds) are central to biomolecular structure and dynamics. Although H-bonds are typically characterized by well-defined proton positions, proton delocalization can play a key role in facilitating enzyme catalysis and allostery in some systems. Experimentally locating protons is difficult, hampering the study of the proton mobility in H-bonds. We used neutron crystallography and large quantum mech...

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Literature Corpus work: 1a5d53a8-d968-5b38-bc42-18b674775adc
DOI: 10.1101/2025.11.05.686872

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