Article

Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI

2021-01-09

Abstract excerpt

<h4>Summary</h4> Epidermal growth factor receptor (EGFR) is mutated or amplified in a majority of glioblastoma (GBM), and its mutation and focal amplification correlate with a more aggressive disease course. However, EGFR-directed tyrosine kinase inhibitors (TKIs) tested to date have yielded minimal clinical benefit. Here, we report a novel covalent-binding EGFR-TKI, CM93, as a potential drug to target adult GBMs...

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Literature Corpus work: 645b653e-05c2-5d83-9f31-a89400a3bea3
DOI: 10.1101/2021.01.09.426030

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