Article

DCE-MRI detects OATP-expressing transplanted cells using clinical doses of gadolinium contrast agent

2024-11-10

Abstract excerpt

<title>Abstract</title> <p>Purpose Hepatic organic anion transporting polypeptides (OATPs) transport off-the-shelf, FDA-approved, hepatospecific Gd-based MRI contrast agents into cells that express the transporters enhancing signal on T1-weighted MRI. Studies have used MRI to identify OATP-overexpressing tumors and metastases transplanted in mice following the delivery of Gd-EOB-DTPA at 27-67-fold higher than cl...

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Literature Corpus work: ab62c982-8a2e-51fa-87c1-e142dc3e6977
DOI: 10.21203/rs.3.rs-5278321/v1

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