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Article

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with <i>in vivo</i> magnetic resonance spectroscopy

17 Aug 1999

Abstract excerpt

Analysis of transgene expression in vivo currently requires destructive and invasive molecular assays of tissue specimens. Noninvasive methodology for assessing the location, magnitude, and duration of transgene expression in vivo will facilitate subject-by-subject correlation of therapeutic outcomes with transgene expression and will be useful in vector development. Cytosine deaminase (CD) is a microbial gene...

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PMID: 10449778
DOI: 10.1073/pnas.96.17.9821

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