Article

Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma

2022-02-16

Abstract excerpt

For the past several decades, chimeric antigen receptor T cell (CAR T) therapies have shown promise in the treatment of cancers. These treatments would greatly benefit from companion imaging biomarkers to follow the trafficking of T cells in vivo . Using synthetic biology, we engineered T cells with a chimeric receptor SyNthetic Intramembrane Proteolysis Receptor (SNIPR) that induces overexpression of an exogenou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e524a042-449c-5947-a61c-2739012e8421
DOI: 10.1101/2022.02.16.480729

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastomaDOI 10.1101/2022.02.16.480729Read

Reporter gene imaging of targeted T cell immunotherapy in recurrent gliomaSemantic proximity Read

T Cell Receptor-Like Recognition of Tumor In Vivo by Synthetic Antibody FragmentSemantic proximity Read

Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imagingSemantic proximity Read

A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapySemantic proximity Read

Synthesis and Comparative Evaluation of 177 Lu-labeled PEG and non-PEG variant peptides as HER2-targeting probesSemantic proximity Read

MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.Semantic proximity Read

A 68Ga–BCMA Ectodomain Tracer Enables PET/MR Longitudinal Tracking of Clinical-Grade BCMA/CD19 CAR T CellsSemantic proximity Read

PET and SPECT Imaging of the EGFR Family (RTK Class I) in OncologySemantic proximity Read

Positron Emission Tomography Reporter Genes and Reporter Probes: Gene and Cell Therapy ApplicationsSemantic proximity Read

Synthetic promoters to induce immune-effectors into the tumor microenvironmentSemantic proximity Read

Visualizing cell–cell communication using synthetic notch activated MRISemantic proximity Read

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastomaSemantic proximity Read