Prediction and Genetic Demonstration of a Role for Activator E2Fs in Myc-Induced Tumors

Abstract excerpt

Advances in genomic signatures have begun to dissect breast cancer heterogeneity and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-induced tumors. We genetically tested this prediction by interbreeding Myc transgenics with mice lacking various...

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