Article
Early Stop Polymorphism in Human DECTIN‐1 Is Associated with Increased <i>Candida</i> Colonization in Hematopoietic Stem Cell Transplant Recipients
17 Jul 2009
Abstract excerpt
Background. Intensive treatment of hematological malignancies with hematopoietic stem cell transplantation (HSCT) is accompanied by a high incidence of opportunistic invasive fungal infection, but individual risk varies significantly. Dectin-1, a C-type lectin that recognizes 1,3-beta-glucans from fungal pathogens, including Candida species, is involved in the initiation of the immune response against fungi....
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