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Article

Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus.

The Journal of rheumatology - 1 Apr 2011

Demirci F Yesim K, Dressen Amy S, Kammerer Candace M, Barmada M Michael, Kao Amy H, Ramsey-Goldman Rosalind, Manzi Susan, Kamboh M Ilyas

Abstract excerpt

OBJECTIVE: Two F2 functional polymorphisms, rs1799963 (G20210A) and rs3136516 (A19911G), are known to be associated with elevated levels/activity of prothrombin (encoded by F2) and risk of thrombosis. Since patients with systemic lupus erythematosus (SLE) have high risk of thrombosis and accelerated atherosclerosis and also high prevalence of anti-prothrombin antibodies, we hypothesized that these two F2...

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Identifiers

PMID: 21239755
DOI: 10.3899/jrheum.100728
PMCID: PMC3073870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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