Article
Factor V Leiden and factor V R2 allele: high-throughput analysis and association with venous thromboembolism.
Thrombosis and haemostasis - 1 Nov 2001
Benson J M, Ellingsen D, El-Jamil M, Jenkins M, Miller C H, Dilley A, Evatt B L, Hooper W C
Abstract excerpt
Thrombophilia is a multigenic disease in which the combination of genetic polymorphisms increases the risk of deep vein thrombosis (DVT). The rapid identification of these genetic combinations requires high-throughput analysis of single nucleotide polymorphisms (SNPs). The TaqMan fluorogenic 5'-->*3' nuclease assay (PE/Applied Biosystems, Foster City, CA) with custom-designed primers, probes and controls has...
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