A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus.

doi:10.1002/art.38520

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Article

A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2014

Kaiser Rachel, Tang Ling Fung, Taylor Kimberly E, Sterba Kirsten, Nititham Joanne, Brown Elizabeth E, Edberg Jeffrey C, McGwin Gerald, Alarcón Graciela S, Ramsey-Goldman Rosalind, Reveille John D, Vilá Luis M, Petri Michelle, Rauch Joyce, Miller Emily, Mesznik Kara, Kwok Pui-Yan, Kimberly Robert P, Salmon Jane E, Criswell Lindsey A

Abstract excerpt

OBJECTIVE: Thrombosis is a serious complication of systemic lupus erythematosus (SLE). Studies that have investigated the genetics of thrombosis in SLE are limited. We undertook this study to assess the association of previously implicated candidate genes, particularly Toll-like receptor (TLR) genes, with pathogenesis of thrombosis. METHODS: We genotyped 3,587 SLE patients from 3 multiethnic populations for 77...

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PMID: 24578102
DOI: 10.1002/art.38520
PMCID: PMC4269184

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TLR2

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