Article
Nonhemolytic Listeria monocytogenes mutants that are also noninvasive for mammalian cells in culture: evidence for coordinate regulation of virulence.
Infection and immunity - 1 Dec 1990
Kathariou S, Pine L, George V, Carlone G M, Holloway B P
Abstract excerpt
We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvas...
Topics
- Animals
- Bacterial Proteins
- Bacterial Toxins
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Female
- Genes, Bacterial
- Heat-Shock Proteins
- Hemolysin Proteins
- Hemolysis
- Listeria monocytogenes
- Mice
- Mice, Inbred ICR
- Mutation
- Phospholipases
- Virulence