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Article

Nonhemolytic Listeria monocytogenes mutants that are also noninvasive for mammalian cells in culture: evidence for coordinate regulation of virulence.

Infection and immunity - 1 Dec 1990

Kathariou S, Pine L, George V, Carlone G M, Holloway B P

Abstract excerpt

We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were deficient not only in the sulfhydryl-activated hemolysin (listeriolysin) but also in an antigenically...

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Identifiers

PMID: 2123830
DOI: 10.1128/iai.58.12.3988-3995.1990
PMCID: PMC313766

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