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Article

Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis.

Virchows Archiv : an international journal of pathology - 1 Feb 2011

Tahara Tomomitsu, Shibata Tomoyuki, Nakamura Masakatsu, Okubo Masaaki, Yamashita Hiromi, Yoshioka Daisuke, Yonemura Joh, Hirata Ichiro, Arisawa Tomiyasu

Abstract excerpt

CpG island hypermethylation (CIHM) is frequently observed in the colonic mucosa in ulcerative colitis (UC) and is deeply involved in UC-associated colorectal carcinogenesis. We evaluated the influence of common polymorphisms related to DNA repair or xenobiotic pathway (XRCC1, GSTP1, GSTT1, and GSTM1) on the individual susceptibility to CIHM status in the non-neoplastic rectal mucosa in UC patients. XRCC1...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21234761
DOI: 10.1007/s00428-010-1038-x

Genes

XRCC1
GSTP1
GSTT1
CDH1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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