Article
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2011
Razorenova Olga V, Finger Elizabeth C, Colavitti Renata, Chernikova Sophia B, Boiko Alexander D, Chan Charles K F, Krieg Adam, Bedogni Barbara, LaGory Edward, Weissman Irving L, Broome-Powell Marianne, Giaccia Amato J
Abstract excerpt
A common genetic mutation found in clear cell renal cell carcinoma (CC-RCC) is the loss of the von Hippel-Lindau (VHL) gene, which results in stabilization of hypoxia-inducible factors (HIFs), and contributes to cancer progression and metastasis. CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis in scirrhous and lung adenocarcinomas as well as in prostate cancer. In this study, we...
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