Article
Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset.
International journal of clinical and experimental pathology - 12 Dec 2010
Jentoft Mark, Giannini Caterina, Cen Ling, Scheithauer Bernd W, Hoesley Bridget, Sarkaria Jann N, Abell-Aleff Patrice C, Rodriguez Erika F, Li Ying, Rodriguez Fausto J
Abstract excerpt
Low grade astrocytomas are the most common CNS tumors in neurofibromatosis type 1(NF1) patients. While most are classic pilocytic astrocytomas (PA), some are difficult to classify, and have been termed "low grade astrocytoma subtype indeterminate" (LGSI). Some of these tumors exhibit peculiar morphologies, including plump cytoplasmic processes and macronucleoli. In the current study we performed electron...
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