Article
Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas.
Critical reviews in oncology/hematology - 1 Aug 2016
Helfferich Jelte, Nijmeijer Ronald, Brouwer Oebele F, Boon Maartje, Fock Annemarie, Hoving Eelco W, Meijer Lisethe, den Dunnen Wilfred F A, de Bont Eveline S J M
Abstract excerpt
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, associated with a variable clinical phenotype including café-au-lait spots, intertriginous freckling, Lisch nodules, neurofibromas, optic pathway gliomas and distinctive bony lesions. NF1 is caused by a mutation in the NF1 gene, which codes for neurofibromin, a large protein involved in the MAPK- and the mTOR-pathway through RAS-RAF signalling. NF1...
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