MAP kinase p38<i>α</i> regulates type III interferon (<i>IFN-</i>λ<i>1</i>) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation

Abstract excerpt

Recognition of viral nucleic acids leads to type I and type III IFN gene expression and activation of host antiviral responses. At present, type III IFN genes are the least well-characterized IFN types. Here, we demonstrate that the p38 MAPK signaling pathway is involved in regulating IFN-λ1 gene expression in response to various types of RNA molecules in human moDCs. Inhibition of p38 MAPK strongly reduced IFN...

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