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Disruption of the Wnt-antagonist <i>Apc</i> in the pituitary stem cells drives the development of adamantinomatous craniopharyngioma

2025-09-29

Abstract excerpt

Adamantinomatous craniopharyngiomas (aCPs) are complex intracranial neoplasms that generally arise in the sellar and suprasellar region of the brain which affect the endocrine and nervous systems causing severe sequelae. Activating mutations resulting in degradation-resistant forms of β-catenin ( CTNNB1 ) have been shown to be the main driver for many of these neoplasms. However, the underlying genetic driver for...

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Literature Corpus work
2126070c-4e97-5e19-a921-978c68c49a56
DOI
10.1101/2025.09.28.679021
Open publication

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Disruption of the Wnt-antagonist <i>Apc</i> in the pituitary stem cells drives the development of adamantinomatous craniopharyngiomaDOI 10.1101/2025.09.28.679021
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