Evolvability and robustness in a complex signalling circuit.

Abstract excerpt

Biological systems at various levels of organisation exhibit robustness, as well as phenotypic variability or evolvability, the ability to evolve novel phenotypes. We still know very little about the relationship between robustness and phenotypic variability at levels of organisation beyond individual macromolecules, and especially for signalling circuits. Here, we examine multiple alternate topologies of the...

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