toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map.

Abstract excerpt

The genotype-phenotype map is an essential object to understand organismal complexity and adaptability. However, its experimental characterisation is a daunting task. Thus, simple models have been proposed and investigated. They have revealed that genotypes differ in their robustness to mutations; phenotypes are represented by a broadly varying number of genotypes, and simple point mutations suffice to navigate...

Topics

• Computational Biology
• Evolution, Molecular
• Gene Regulatory Networks
• Genotype
• Models, Genetic
• Mutation
• Phenotype