Article
Evidence for a fast, intrachromosomal conversion mechanism from mapping of nucleotide variants within a homogeneous alpha-satellite DNA array.
Genome research - 1 Dec 2002
Schindelhauer Dirk, Schwarz Tobias
Abstract excerpt
Assuming that patterns of sequence variants within highly homogeneous centromeric tandem repeat arrays can tell us which molecular turnover mechanisms are presently at work, we analyzed the alpha-satellite tandem repeat array DXZ1 of one human X chromosome. Here we present accurate snapshots from this dark matter of the genome. We demonstrate stable and representative cloning of the array in a P1 artificial...
Topics
- Animals
- Centromere
- Chromosomes, Artificial, P1 Bacteriophage
- DNA, Satellite
- Gene Conversion
- Gene Duplication
- Genetic Variation
- Gorilla gorilla
- Haplotypes
- Humans
- Male
- Molecular Sequence Data
- Nucleotides
- Oligonucleotide Array Sequence Analysis
- Recombination, Genetic
- Restriction Mapping
- X Chromosome