Segmental duplications flank the multiple sclerosis locus on chromosome 17q.

doi:10.1101/gr.2340804

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Article

Segmental duplications flank the multiple sclerosis locus on chromosome 17q.

Genome research - 1 Aug 2004

Chen Daniel C, Saarela Janna, Clark Royden A, Miettinen Timo, Chi Anthony, Eichler Evan E, Peltonen Leena, Palotie Aarno

Abstract excerpt

Large chromosomal rearrangements, duplications, and inversions are relatively common in mammalian genomes. Here we report interesting features of DNA strands flanking a Multiple Sclerosis (MS) susceptibility locus on Chromosome 17q24. During the positional cloning process of this 3-Mb locus, several markers showed a radiation hybrid clone retention rate above the average (1.8-fold), suggestive for the existence...

Topics

Animals
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Gene Duplication
Genetic Markers
Genome, Human
Haplotypes
Humans
Mice
Models, Molecular
Multiple Sclerosis
Polymorphism, Single Nucleotide
Radiation Hybrid Mapping

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Sequence Homology, Nucleic Acid

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Identifiers

PMID: 15256512
DOI: 10.1101/gr.2340804
PMCID: PMC509257

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