Article
An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection.
Vaccine - 17 Feb 2011
Pesciaroli M, Aloisio F, Ammendola S, Pistoia C, Petrucci P, Tarantino M, Francia M, Battistoni A, Pasquali P
Abstract excerpt
Salmonella enterica serovar Typhimurium has long been recognised as a zoonotic pathogen of economic significance in animals and humans. Attempts to protect humans and livestock may be based on immunization with vaccines aimed to induce a protective response. We recently demonstrated that the oral administration of a Salmonella enterica serovar Typhimurium strain unable to synthesize the zinc transporter ZnuABC is...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Disease Models, Animal
- Enterocolitis
- Female
- Genetic Predisposition to Disease
- Intestinal Mucosa
- Mice
- Mice, Inbred DBA
- Mutation
- Random Allocation
- Salmonella Infections, Animal
- Salmonella Vaccines