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Article

A Novel Antimicrobial Approach Based on the Inhibition of Zinc Uptake in Salmonella Enterica

1 Jun 2017

Abstract excerpt

In this review we discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies. The ability of the gut pathogen Salmonella enterica sv Typhimurium to withstand the host responses aimed at controlling growth of the pathogen critically depends on the zinc importer ZnuABC. Strains lacking a functional ZnuABC or its soluble component ZnuA display a...

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PMID: 28636417
DOI: 10.4155/fmc-2017-0042

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