Article
The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jan 2011
Sachs-Erisson Natalie, Sawyer Kathryn, Corsentino Elizabeth, Collins Nicole, Steffens David C
Abstract excerpt
OBJECTIVE: the apolipoprotein E epsilon-4 (APOE [small element of] 4) allele and depression are independently associated with increased risk for cognitive decline (CD). The authors have reported that depressed elders with an APOE [small element of]4 allele had greater CD compared with depressed elders without the allele. Depression affects the hippocampus, and reduced hippocampal volume has been associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.