Article
Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.
Genetics and molecular research : GMR - 4 Jan 2011
Saricaoglu H, Yilmaz M, Karkucak M, Ozturk H Z Y, Yakut T, Gulten T, Baskan E B, Aydogan K, Dilek K
Abstract excerpt
Colchicine is commonly used in the treatment of Behçet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behçet's disease. We randomly selected 97 patients...
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