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Article

Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever.

The Journal of rheumatology - 1 Jul 2007

Tufan Abdurrahman, Babaoglu Melih O, Akdogan Ali, Yasar Umit, Calguneri Meral, Kalyoncu Umut, Karadag Omer, Hayran Mutlu, Ertenli A Ihsan, Bozkurt Atila, Kiraz Sedat

Abstract excerpt

OBJECTIVE: Colchicine is a mainstay of treatment in familial Mediterranean fever (FMF); however, 5%-10% of patients do not respond to colchicine. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1 or MDR1) is a drug transporter that extrudes colchicine out of cells. ABCB1 gene 34...

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Source

Identifiers

PMID: 17610314

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17610314-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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