Article
The association of aromatase (CYP19) gene variants with sperm concentration and motility.
Asian journal of andrology - 1 Mar 2011
Lazaros Leandros, Xita Nectaria, Kaponis Apostolos, Hatzi Elissavet, Plachouras Nicolaos, Sofikitis Nicolaos, Zikopoulos Konstantinos, Georgiou Ioannis
Abstract excerpt
The irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the (TTTA)(n) polymorphism in the aromatase gene (CYP19) to sperm concentration and motility. Ninety normozoospermic and 60 oligospermic men were examined during infertility examinations. DNA was extracted from spermatozoa, and the CYP19 (TTTA)(n)...
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