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Article

Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

Human reproduction (Oxford, England) - 1 Jun 2011

Lee I-Wen, Kuo Po-Hsiu, Su Mei-Tsz, Kuan Long-Ching, Hsu Chao-Chin, Kuo Pao-Lin

Abstract excerpt

BACKGROUND: Human spermatogenesis is regulated by complex networks, and estrogens are recognized as one of the significant regulators of spermatogenesis. We tested the associations between variants of estrogen-related genes and semen parameters. METHODS: We performed genotyping for genetic variants of estrogen-related genes and quantitative trait analysis of fertile and infertile men with well-characterized...

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Topics

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Share to Estrogens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Polymorphism, Genetic

Share to Quantitative Trait, Heritable

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Share to Sperm Motility

Share to Spermatogenesis

Source

Identifiers

PMID: 21429951
DOI: 10.1093/humrep/der062

Genes

SHBG
COMT
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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