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Article

Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

The Journal of infectious diseases - 15 Feb 2011

López-Rojas Rafael, Domínguez-Herrera Juan, McConnell Michael J, Docobo-Peréz Fernando, Smani Younes, Fernández-Reyes María, Rivas Luis, Pachón Jerónimo

Abstract excerpt

Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model...

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Identifiers

PMID: 21216865
DOI: 10.1093/infdis/jiq086
PMCID: PMC3071218

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Source receipt: pubmed, retrieved 7 Sept 2026.

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