Article
Molecular analysis of the York antigen of the Knops blood group system.
Transfusion - 1 Jul 2011
Veldhuisen Barbera, Ligthart Peter C, Vidarsson Gestur, Roels Ingrid, Folman Claudia C, van der Schoot C Ellen, de Haas Masja
Abstract excerpt
BACKGROUND: Antigens of the Knops blood group system are present on complement component (3b/4b) receptor 1 (CR1/CD35), which is a transmembrane glycoprotein encoded by the CR1 gene. Eight of the nine known antigens of this system are linked to polymorphisms in Exon 29. The molecular background of one antigen, York (Yk(a)), has not yet been described. STUDY DESIGN AND METHODS: We aimed to identify a polymorphism...
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