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Article

Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.

Genetics - 1 Mar 2011

Hayakawa Teruyuki, Kato Kumiko, Hayakawa Ryoichi, Hisamoto Naoki, Matsumoto Kunihiro, Takeda Kohsuke, Ichijo Hidenori

Abstract excerpt

Cells and organisms face anoxia in a wide variety of contexts, including ischemia and hibernation. Cells respond to anoxic conditions through multiple signaling pathways. We report that NSY-1, the Caenorhabditis elegans ortholog of mammalian apoptosis signal-regulating kinase (ASK) family of MAP kinase (MAPK) kinase kinases (MAP3Ks), regulates viability of animals in anoxia. Loss-of-function mutations of nsy-1...

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Identifiers

PMID: 21212236
DOI: 10.1534/genetics.110.124883
PMCID: PMC3063672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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