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Article

Contribution of TNF-α to the development of retinal neurodegenerative disorders

1 Mar 2013

Abstract excerpt

During the late 1970s, tumor necrosis factor alpha (TNF-α) was initially recognized as an endotoxin-induced substance that was mainly produced by macrophages, and able to cause the lysis of certain tumor cells. Subsequent research demonstrated that TNF-α mediates a broad range of cellular activities, including proliferation, survival, differentiation and apoptosis. It is also considered to be essential for the...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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Identifiers

PMID: 23608634
DOI: 10.1684/ecn.2013.0334

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