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Article

MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.

Mutation research - 18 Mar 2011

Pardini Barbara, Kumar Rajiv, Naccarati Alessio, Prasad Rashmi B, Forsti Asta, Polakova Veronika, Vodickova Ludmila, Novotny Jan, Hemminki Kari, Vodicka Pavel

Abstract excerpt

Polymorphic variants in genes involved in one-carbon metabolism, in particular of dietary folate, may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms a...

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Source

Identifiers

PMID: 21211571
DOI: 10.1016/j.mrgentox.2010.12.008

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21211571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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