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Article

Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome

6 Jan 2011

Abstract excerpt

BACKGROUND: Myelodysplastic syndrome with isolated chromosome 5q deletion (5q- syndrome) is a clonal stem cell disorder characterized by ineffective hematopoiesis. MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. Further, we studied...

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PMID: 21211043
DOI: 10.1186/1756-8722-4-1

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