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Article

Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production<i>In Vivo</i>

2 Jul 2003

Abstract excerpt

Epidemiology, in vitro, and in vivo studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). We have examined the impact of aberrant intracellular cholesterol transport on the processing of the amyloid precursor protein (APP) in a mouse model of Niemann-Pick type C (NPC) disease. In the NPC mouse brain, cholesterol accumulates in late endosomes/lysosomes. This was...

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PMID: 12843267
DOI: 10.1523/jneurosci.23-13-05645.2003

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Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production<i>In Vivo</i>PMID 12843267Read ↗

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