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Transcriptional Regulation of Telomerase Activity

1 Oct 2007

Abstract excerpt

Telomerase maintains telomeres to preclude cell senescence. It remains elusive how telomerase activity is repressed in differentiated cells, but retained at high levels in stem cells and cancer. Recent studies suggest that the Ets transcription factor family, downstream of the mitogen signaling pathways of MAP kinase, regulates telomerase activity at the gene transcription level of human telomerase reverse...

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Share to Mesenchymal stem cell research
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PMID: 17986575
DOI: 10.1196/annals.1396.022

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