Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2011

Griol-Charhbili Violaine, Fassot Céline, Messaoudi Smail, Perret Claudine, Agrapart Vincent, Jaisser Frederic

Abstract excerpt

Pathophysiological aldosterone (aldo)/mineralocorticoid receptor signaling has a major impact on the cardiovascular system, resulting in hypertension and vascular remodeling. Mineralocorticoids induce endothelial dysfunction, decreasing vasorelaxation in response to acetylcholine and increasing the response to vasoconstrictors. Activation of the epidermal growth factor receptor (EGFR) is thought to mediate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Aldosterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nephrectomy

Share to Nitroprusside

Share to Phenylephrine

Share to Vasoconstriction

Share to Vasoconstrictor Agents

Share to Vasodilator Agents

Source

Identifiers

PMID: 21199998
DOI: 10.1161/HYPERTENSIONAHA.110.153619

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt.PMID 21199998Read ↗

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.Semantic proximity Read ↗

Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways.Semantic proximity Read ↗

The epoxyeicosatrienoic pathway is intact in endothelial and smooth muscle cells exposed to aldosterone excessSemantic proximity Read ↗

Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.Semantic proximity Read ↗

Angiotensin II and the vascular phenotype in hypertension.Semantic proximity Read ↗

Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress–Dependent and –Independent PathwaysSemantic proximity Read ↗

Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats.Semantic proximity Read ↗

Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse ModelsSemantic proximity Read ↗

The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.Semantic proximity Read ↗

Renal arterial dysfunction, impaired pressure natriuresis and salt-sensitivity in a mouse model of Cushing syndromeSemantic proximity Read ↗

An evolutionarily conserved olfactory receptor is required for sex differences in blood pressureSemantic proximity Read ↗

Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.