Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.

Scientific reports - 24 Jun 2021

Stroedecke Katharina, Meinel Sandra, Markwardt Fritz, Kloeckner Udo, Straetz Nicole, Quarch Katja, Schreier Barbara, Kopf Michael, Gekle Michael, Grossmann Claudia

Abstract excerpt

The EGF receptor (EGFR) has been extensively studied in tumor biology and recently a role in cardiovascular pathophysiology was suggested. The mineralocorticoid receptor (MR) is an important effector of the renin-angiotensin-aldosterone-system and elicits pathophysiological effects in the cardiovascular system; however, the underlying molecular mechanisms are unclear. Our aim was to investigate the importance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldosterone
Share to Calcium Channels, T-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular System

Share to ErbB Receptors

Share to HEK293 Cells

Share to Hypertrophy

Share to Myocytes, Cardiac

Share to Receptors, Mineralocorticoid

Source

Open in PubMed Open full text

Identifiers

PMID: 34168192
DOI: 10.1038/s41598-021-92284-y
PMCID: PMC8225817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.PMID 34168192Read ↗

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and DiseaseSemantic proximity Read ↗

The Mineralocorticoid Receptor: Insights into its Molecular and (Patho)Physiological BiologySemantic proximity Read ↗

Aldosterone Stimulates Epidermal Growth Factor Receptor ExpressionSemantic proximity Read ↗

GRK5 is an Essential Co-repressor for Cardiac Mineralocorticoid Receptor Antagonism induced by Finerenone but not EplerenoneSemantic proximity Read ↗

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt.Semantic proximity Read ↗

Epidermal growth factor (EGF) receptor family signalling in cardiomyocyte hypertrophy and heart failureSemantic proximity Read ↗

Beclin-1 restrains aldosterone signaling via autophagic degradation of the mineralocorticoid receptor to protect against cardiovascular injurySemantic proximity Read ↗

GPR48 Increases Mineralocorticoid Receptor Gene ExpressionSemantic proximity Read ↗

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cellsSemantic proximity Read ↗

Evolving research in nongenomic actions of aldosteroneSemantic proximity Read ↗

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by AldosteroneSemantic proximity Read ↗

Heart Disease in Women: Unappreciated Challenges, GPER as a New Target.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.