Article

The epoxyeicosatrienoic pathway is intact in endothelial and smooth muscle cells exposed to aldosterone excess

2021-02-05

Abstract excerpt

<h4>Objectives</h4> Endothelial dysfunction (ED) is considered to be a major driver of the increased incidence of cardiovascular disease in primary aldosteronism (PA). Whether the epoxyeicosatrienoic acid (EET) pathway, involving the release of beneficial endothelium-derived lipid mediators, contributes to ED in PA is unknown. Preclinical evidence suggests this pathway to be relevant in the pathogenesis in variou...

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Literature Corpus work: d53a0425-ccbd-53e9-9b3f-a825e8c85e83
DOI: 10.1101/2021.02.04.429624

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