Cataract-causing mutations L45P and Y46D impair the thermal stability of γC-crystallin.

doi:10.1016/j.bbrc.2020.12.096

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cataract-causing mutations L45P and Y46D impair the thermal stability of γC-crystallin.

Biochemical and biophysical research communications - 5 Feb 2021

Fu Chenxi, Xu Jingjie, Yang Xiaoxia, Chen Xiangjun, Yao Ke

Abstract excerpt

Crystallin gene mutations are responsible for about half of the congenital cataract caused by genetic disorders. L45P and Y46D mutations of γC-crystallin have been reported in patients with nuclear congenital cataract. In this study, we explored the thermal stability of wild type (WT), L45P, and Y46D mutants of γC-crystallin at low and high concentrations, as well as the effect of αA-crystallin on the thermal...

Topics

Cataract
Cryoelectron Microscopy
Humans
Mutation
Protein Stability
Recombinant Proteins
Temperature
gamma-Crystallins

Source

Open in PubMed

Identifiers

PMID: 33422942
DOI: 10.1016/j.bbrc.2020.12.096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics