Article
Association of IL-17RB gene polymorphism with asthma.
Chest - 1 May 2009
Jung Ji-Sun, Park Byung Lae, Cheong Hyun Sub, Bae Joon Seol, Kim Ji-Hye, Chang Hun Soo, Rhim TaiYoun, Park Jong-Sook, Jang An-Soo, Lee Young-Mok, Kim Ki-Up, Uh Soo-Taek, Na Ju Ock, Kim Yong-Hoon, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
BACKGROUND: Interleukin (IL)-17E is a member of the IL-17 family, which induces IL-4, IL-5, IL-13, and eotaxin in experimental animals via IL-17 receptor B (IL-17RB). The activation of IL-17RB amplifies allergic-type inflammatory responses by inducing Jun kinase (or JNK), p38 mitogen-activated protein kinase (or MAPK), and nuclear factor-kappaB. OBJECTIVES: We examined the association of polymorphisms in the...
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