Article
Potential involvement of IL-17F in asthma.
Journal of immunology research - 1 Jan 2014
Ota Kyoko, Kawaguchi Mio, Matsukura Satoshi, Kurokawa Masatsugu, Kokubu Fumio, Fujita Junichi, Morishima Yuko, Huang Shau-Ku, Ishii Yukio, Satoh Hiroaki, Hizawa Nobuyuki
Abstract excerpt
The expression of IL-17F is seen in the airway of asthmatics and its level is correlated with disease severity. Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway...
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