Article
Interleukin 17A and F and asthma in Saudi Arabia: gene polymorphisms and protein levels.
Journal of investigational allergology & clinical immunology - 1 Jan 2011
Bazzi M D, Sultan M A, Al Tassan N, Alanazi M, Al-Amri A, Al-Hajjaj M S, Al-Muhsen S, Alba-Concepcion K, Warsy A
Abstract excerpt
BACKGROUND: Asthma is a multifactorial disorder, and both genetic and environmental factors contribute to its development. We investigated the possible association between asthma and 5 single-nucleotide polymorphisms (SNPs) in the interleukin 17 (IL17) gene--rs17880588 (G/A) and rs17878530 (C/T) in IL17A and rs763780 (T/C), rs11465553 (T/C), and rs2397084 (G/A) in IL17F--and compared levels of the proteins IL17A...