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Article

Regulation of Mouse Spermatogonial Stem Cell Differentiation by STAT3 Signaling1

27 May 2010

Abstract excerpt

Homeostasis of many tissues is maintained by self-renewal and differentiation of stem cells. Spermatogenesis is one such system relying on the activity of spermatogonial stem cells (SSCs). Several key regulators of SSC self-renewal have been identified, yet knowledge of molecules that control SSC differentiation is undefined. In this study, we found that transient impairment of STAT3 signaling enhances SSC...

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PMID: 20505165
DOI: 10.1095/biolreprod.109.083352

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