Article
Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS).
Circulation. Heart failure - 1 Mar 2011
Bhuiyan Taslima, Helmke Stephen, Patel Ayan R, Ruberg Frederick L, Packman Jeff, Cheung Kin, Grogan Donna, Maurer Mathew S
Abstract excerpt
BACKGROUND: ATTR cardiac amyloidosis can result from a mutated variant of transthyretin (eg, V122I) or wild-type variant (ATTRwt). We evaluated pressure-volume (PV) indices at baseline and over time to further characterize abnormal pump function in these subjects. METHODS AND RESULTS: Twenty-nine subjects (18 with ATTRwt and 11 with ATTRm (V122I) had 2-dimensional echocardiograms with complete Doppler measures at...
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