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Article

The amyloidogenic V122I transthyretin variant in elderly black Americans.

The New England journal of medicine - 1 Jan 2015

Quarta C Cristina, Buxbaum Joel N, Shah Amil M, Falk Rodney H, Claggett Brian, Kitzman Dalane W, Mosley Thomas H, Butler Kenneth R, Boerwinkle Eric, Solomon Scott D

Abstract excerpt

BACKGROUND: Approximately 4% of black Americans carry a valine-to-isoleucine substitution (V122I) in the transthyretin protein, which has been associated with late-onset restrictive amyloid cardiomyopathy and increased risks of death and heart failure. METHODS: We determined genotype status for the transthyretin gene (TTR) in 3856 black participants in the Atherosclerosis Risk in Communities study and assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25551524
DOI: 10.1056/NEJMoa1404852
PMCID: PMC4382209

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The amyloidogenic V122I transthyretin variant in elderly black Americans.PMID 25551524Read ↗

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