Article
Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: the Transthyretin Amyloidosis Cardiac Study (TRACS).
American heart journal - 1 Aug 2012
Ruberg Frederick L, Maurer Mathew S, Judge Daniel P, Zeldenrust Steven, Skinner Martha, Kim Antony Y, Falk Rodney H, Cheung Kin N, Patel Ayan R, Pano Arian, Packman Jeffrey, Grogan Donna Roy
Abstract excerpt
BACKGROUND: TRACS sought to describe the clinical outcomes and disease progression of transthyretin (TTR) cardiac amyloidosis (ATTR) in an observational study. Clinical course is largely determined by disease type with ATTR categorized as wild-type (ATTRwt) or genetic-variant protein (ATTRm). Prospective data are lacking in the most common TTR mutation, V122I, present in approximately 3.5% of African Americans....
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