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Article

Clinical Implications of the Amyloidogenic V122I Transthyretin Variant in the General Population.

Journal of cardiac failure - 1 Mar 2022

Kozlitina Julia, Garg Sonia, Drazner Mark H, Matulevicius Susan A, Ayers Colby, Overton John, Reid Jeffrey, Baras Aris, Rao Krishnasree, Pandey Ambarish, Berry Jarett, de Lemos James A, Grodin Justin L

Abstract excerpt

BACKGROUND: The V122I variant in transthyretin (TTR) is the most common amyloidogenic mutation worldwide. The aim of this study is to describe the cardiac phenotype and risk for adverse cardiovascular outcomes of young V122I TTR carriers in the general population. METHODS AND RESULTS: TTR genotypes were extracted from whole-exome sequence data in participants of the Dallas Heart Study. Participants with African...

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Identifiers

PMID: 34634447
DOI: 10.1016/j.cardfail.2021.09.015
PMCID: PMC8923911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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